Thinakaran Lab - Cell Biology of Alzheimer's Disease

Thinakaran and Parent Labs held their Annual Holiday Lunch. The pictures from the Hot Pot Lunch our traditional gift exchange are in this link - click here

Congratulations to Shuai and Moorthi - co-first authors of the manuscript " Spatiotemporal transcriptomic profiling reveals metabolic dysfunction prior to overt tauopathy in the PS19 mouse model ", which is accepted in Experimental Molecular Medicine .

Danielle Blazier successfully defended her thesis research on October 8, 2025.

Our research on PICALM, published in Nature , was highlighted in a USF Health News: "Gene variant slows down removal of debris in the brain, increasing Alzheimer’s risk, say USF Health researchers" https://bit.ly/47AAjxY

Congratulations to all authors!   We are excited to share our recent publication in Nature: PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia. This paper is the outcome of a wonderful collaboration between our lab and the Duan Lab at Endeavor Health Research Institute and the University of Chicago https://www.nature.com/articles/s41586-025-09486-x .

Congratulations to Danielle Blazier on the publication of her thesis research in the Journal of Biological Chemistry . Danielle discovered and characterized the interaction of BIN1's SH3 domain with p140Cap. https://www.jbc.org/article/S0021-9258(25)02517-7/fulltext

Congratulations to Joe McMillan. His thesis work on TurboID proximity labeling and proteomic characterization of the BIN1's interactome was published in Molecular and Cellular Proteomics . https://www.mcponline.org/article/S1535-9476(25)00154-9/fulltext

Joe McMillan successfully defended his thesis research on March 25, 2025.

Congratulations to Daniel for securing an Alzheimer's Association Research Fellowship for his project entitled "The role of AD risk...

Melike and Carlos decided to tie the knot. We wish them all the happiness in the world.

Congratulations to Ari on his success in receiving a BrightFocus fellowship!

Congratulations to all authors! We are excited to share our recent publication in Brain: Loss of forebrain BIN1 attenuates...

Congratulations for his success in securing an Alzheimer's Association Research Fellowship for his project entitled "Elucidating the role...

Congratulations to all authors! We are excited to share our recent publication in Molecular Neurodegeneration: BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia. bit.ly/3sjRTCq This paper is the outcome of a wonderful collaboration between our lab and the Rangaraju Lab at Emory University.

A video highlighting how USF Health is pushing the reaches of academic medicine forward at the USF Health Morsani College of Medicine to...

Our recent paper on BIN1 has been featured in the news. https://www.eurekalert.org/pub_releases/2020-03/uosf-bdi031120.php...

Our lab has been profiled in the USF Health News https://hscweb3.hsc.usf.edu/blog/tag/gopal-thinakaran/

Congratulations to our collaborators and contributors. Our manuscript describing the characterization of BIN1 neuronal cKO mice has been...

Timeline August 1, 2019: Thinakaran lab moves to the USF Health Neuroscience Institute / Byrd Alzheimer's Center and Research Institute...