Selected Publications
Blazier DM, Lewandowski EM, Ram N, Zhang X, Wang S, Patel O, Collier L, Defilippi P, Chen Y, and Thinakaran G: A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap. J. Biol. Chem. 2025. doi: 10.1016/j.jbc.2025.110665. PMID: 40889683. Full Text
McMillan JD, Wang S, Wohlfahrt J, Guergues J, Stevens SM Jr., and Thinakaran G: Proteomic characterization of the Alzheimer’s disease risk factor BIN1 interactome. Molecular and Cellular Proteomics, 2025. doi: 10.1016/j.mcpro.2025.101055. PMID: 40835006. Full Text
Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Byeon SK, Thapa C, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Schneider JA, Pandey A, Bennett DA, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G†, and Duan J†: PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia. Nature, 2025. doi: 10.21203/rs.3.rs-4407146/v1. PMID: 40903578. Full Text
Zhao X, Li Y, Zhang S; Sudwarts A, Zhang H, Kozlova A, Moulton MJ, Goodman LD, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, and Duan J: Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication. Molecular Neurodegeneration, 2025, 20(1):51. doi: 10.1101/2024.08.14.24312009. PMID: 39185522. Full Text
Moreira-Silva D, Yuksel M, Ponnusamy M, Hansen MT, McMillan JD, Geethakrishnan S, Wang S, Collier LA, and Thinakaran G: Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity. Genes & Diseases, 2025. 12, 101602. doi:10.1016/j.gendis. 2025.101602. https://doi.org/10.1016/j.gendis.2025.101602.
Aow J, Huang, T-R, Goh, Y-T, Xu A, Sun Y, Thinakaran G, and Koo EH. Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment. Cell Reports, 2023. 42(7):112774. doi: 10.1016/j.celrep.2023.112774. Full Text
Sudwarts A., and Thinakaran G: Alzheimer’s genes in microglia: a risk worth investigating. Molecular Neurodegeneration, 2023, 20;18(1):90. doi: 10.1186/s13024-023-00679-4. Full Text
Ponnusamy M, Wang S, Yuksel M, Hansen MT, Blazier DM, McMillan JD, Zhang X, Dammer EB, Collier L, and Thinakaran G. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain, 2023. 146(4):1561-1579. doi: 10.1093/brain/awac318. Full Text
Sudwarts S, Ramesha S, Gao T, Ponnusamy P, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, Thinakaran G, and Rangaraju S. BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia. Molecular Neurodegeneration, 2022. 17(1):33. doi: 10.1186/s13024-022-00535-x. Full Text
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Aleksandra J Recupero1. Thomas Le Metayer1, Hansen MT, Ha-Na Shim H-N, Sofia V Krause SV, Freedman DJ, Vytas P Bindokas VP, Narayanan Kasthuri N, Nicholson DA, Contractor A, Thinakaran G: Neuronal BIN1 regulates presynaptic neurotransmitter release and memory consolidation. Cell Reports, 2020, 30(10)P3520-3535. Full Text.
Andrew RJ, De Rossi P, Nguyen P, Kowalski HR, Recupero AJ, Guerbette T, Krause SV, Rice RC, Laury-Kleintop L, Wagner SL, and Thinakaran G: Reduction of late-onset Alzheimer’s disease risk-factor BIN1 expression does not affect amyloid pathology in a mouse model of Alzheimer’s disease. J. Biol. Chem. 2019. 294(12):4477-4487. Full Text
De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l’Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, and Thinakaran G: Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic models. Brain Pathology, 2018. doi: 10.1111/bpa.12687. Full Text
Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, and Thinakaran G: Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease. Proc. Natl. Acad. Sci. USA, 2017. 114(45):E9665-E9674.
De Rossi P, Buggia-Prévot V, Clayton BLL, Vasquez JB, van Sanford C, Andrew RJ, Lesnick R, Botté A, Deyts C, Salem S, Rao E, Rice RC, Parent A, Kar S, Popko B, Pytel P, Estus S, and Thinakaran G: Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts. Molecular Neurodegeneration, 2016, 11:59. DOI 10.1186/s13024-016-0124-1. Full Text
Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, and Thinakaran G: Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Molecular Neurodegeneration, 9:1, 2014. Full Text
Buggia-Prévot V, Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S, George M, Kar S, Bindokas VP, Parent AT, Rajendran L, Band H, Vassar R and Thinakaran G: A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer's Disease Aβ production. Cell Reports, 2013, 5: 1552–1563. Full Text / PDF / Movies