As a senior undergraduate student, I carried out my graduation project in Bio-X Institutes of SJTU, focusing on a brachydactylic gene. Since then, I have been fascinated by animal models of genetic diseases. Thus, for my Ph.D. thesis, I worked on the X-chromosome-linked intellectual disability candidate gene Phf8. The loss of Phf8 expression in mice causes learning and memory deficits by the epigenetic disruption of mTOR signaling. Pharmacological suppression of mTOR signaling in Phf8 knockout mice recovered the weakened LTP and cognitive deficits. These findings provide a potential therapeutic drug target to treat XLID. In the Thinakaran lab, I am investigating the role of RNA modifications in the brain and AD pathogenesis, and the function of BIN1, using KO and transgenic mouse models.