Thinakaran Lab - Cell Biology of Alzheimer's Disease

I completed my PhD in Neuroscience at the Centre for Brain Research, focusing on synaptic dysfunction in Alzheimer’s disease. My research explored how loss of the actin cytoskeleton, a key structural component of synapses, contributes to impaired synaptic integrity, altered glutamatergic signalling, and cognitive decline. Using a combination of mass spectrometry, primary neuronal cultures, and postmortem human brain analysis, I investigated how disrupted PSD-95–actin interactions contribute to synaptic deficits in Alzheimer’s disease and showed that stabilizing F-actin can restore synaptic structure and function, highlighting a potential therapeutic strategy. In Prof. Thinakaran’s lab, I am working on human BIN1 overexpression and its role in tau pathogenesis and neuroinflammation in Alzheimer’s disease.