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Neuronal BIN1 modulates tau pathology

Congratulations to all authors! We are excited to share our recent publication in Brain: Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model.

Forebrain neuronal BIN1 expression promotes hippocampal tau pathogenesis and neuroinflammation. Our findings highlight an exciting region-specificity in neuronal BIN1 regulation of tau pathogenesis and reveal cell-autonomous and non-cell-autonomous mechanisms involved in BIN1 modulation of tau neuropathology.

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